Why the study?
Low-temperature exposure causes cryoactivation of prorenin to renin, yielding falsely elevated renin concentrations.
Population
Plasma samples
Comparison
Different storage temperatures and protease inhibitors with or without 2-hour incubation at 37 °C
Design
Laboratory evaluation study
Authors
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Requires careful temperature control for renin samples; leaves open optimal handling protocols.
Cryoactivation of renin in plasma samples stored at -20 °C can be reversed by a 2-hour incubation at 37 °C when using trypsin inhibitor or protease inhibitor cocktail tubes, offering an alternative for labs lacking -80 °C storage.
Özcan et al. (2025) studied this question.