In men with essential hypertension, a disturbed TNF system is associated with chronic inflammation and mild renal dysfunction rather than insulin resistance.
TNF receptors linked to inflammation and mild renal dysfunction in hypertensive men; hypothesis-generating, with causality and therapeutic relevance left open.
Background The relationship between tumor necrosis factor (TNF)-related parameters and cardiorenal metabolic factors is still controversial in clinical hypertension. Methods Normotensive men (NT, n=60) and treated stage 2 and 3 essential hypertensive men (HT, n=89) were enrolled in this study. The relationship between TNF-related parameters and cardiorenal metabolic factors was examined in NT and HT, separately. Results HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. The levels of soluble TNF receptor 1 and 2 were significantly higher in HT than in NT, although TNF-α levels were unexpectedly lower in HT than in NT. Regression analysis indicated that the TNF-related parameters were closely linked with mild renal dysfunction both in NT and HT, and moderately related to chronic inflammation only in HT. HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters. Conclusion These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT.
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Eguchi et al. (2014) studied this question.
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