Further Daphniphyllum Alkaloids from the Bark of Daphniphyllum macropodum Miq.

Four new Daphniphyllum alkaloids, namely dehydroxymacropodumine A (1), 4,21‐deacetyl‐23‐demethyl‐deoxyyuzurimine (2), 7‐oxo‐deoxyyuzurimine (3), and 4‐acetoxydaphmanidin B (4), together with seven known related alkaloids, were isolated from the bark of Daphniphyllum macropodum Miq. The structures of new compounds 1–4 including relative configurations were elucidated on the basis of detailed spectroscopic data analysis and by comparison with related known compounds. Dehydroxymacropodumine A (1) possesses a rare eleven‐membered macrolactone ring representing the second example of this backbone isolated from natural sources.