Evaluation of TGF-β isoforms based on selected clinical parameters in asthmatic patients

The transforming growth factor (TGF-) has attracted particular attention from researchers in the context of the pathogenesis and development of asthma and allergic diseases. Undoubtedly, TGF- is one of the main cytokines involved in mediating inflammation and bronchial remodeling. It stimulates fibroblasts and myofibroblasts, and regulates processes of extracellular matrix remodeling, thus contributing to fibrosis and bronchial remodeling. In long-term inflammation, the airways become stiffened and airflow is impaired, which is sometimes reflected by lower values of spirometric parameters. What may also be observed in aging organs is intensified fibrotic processes. Aim: To evaluate the correlation between concentrations of all the TGF- 1-3 isoforms and selected clinical parameters, including pulmonary function indices assessed by spirometry.