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An antiscrum was made in a rabbit against pig IL-1 (catabolin) The antiscrum was shown by Western blot to react with the antigen and also to cross-react with certain other slightly larger leucocyte proteins The antiserum directly inhibited the action of pig IL-1 in a mouse thvmocytc assay and also prevented it from inducing rcsorption of proteoglycan in explants of bovine nasal cartilage The antiserum inhibited partially purified human IL-1 of pl 5.0 m both the thymocyte and cartilage assays, but it did not interact with the human IL-1 of pl 7.0 The results suggest that pig IL-1 (catabolin) and human IL-1 pl 5.0 may be related and that the human IL-lsare immunologically different.
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Saklatvala et al. (1985) studied this question.
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