Fat utilization by muscle

Determinations of the carboxylase activity of the yeast indicate that no quantitative adaptation had occurred as a result of growth in the presence of cocaine.SUMMARY 1.The effects of cocaine and of added vitamin B1 on the glucose fermentation of Saccharomyces cerevi8iae at pH 7, previously grown in the presence and in the absence of cocaine, have been compared.There is a difference in behaviour towards added vitamin B1 between the normal yeast and the cocaine-grown yeast.2. Cocaine in concentration sufficient to arrest growth (0005M) at pH 7 inhibits completely the carboxylase system of S. cerevi8iae.3. The carboxylase systems of yeast grown in the presence and in the absence of cocaine are inhibited by cocaine to a similar extent.4. No quantitative adaptation of the carboxylase system of S. cerevi8iae has been found as a result of growth in the presence of cocaine at pH 7.