The cost-effectiveness threshold commonly used is country's per capita gross domestic product (GDP) based on a report by the Commission on Macroeconomics and Health. The WHO threshold is divided into 3 groups: highly cost-effective (less than GDP per capita), cost-effective (1-3 times GDP per capita), and not cost-effective (more than 3 times GDP per capita). These thresholds are commonly used in cost-effectiveness studies but they do not always reflect affordability.
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Kari Natunen (2013) studied this question.