Resident memory CD8 T cells persist for years in human small intestine

In human small intestine, most CD8 T cells in the lamina propria and epithelium express a resident memory (Trm) phenotype and persist for at least one year in transplanted tissue. Intestinal CD8 Trm cells have a clonally expanded immune repertoire that is stable over time and exhibit enhanced protective capabilities. Graphical abstract Highlights The vast majority of CD8 T cells in the human small intestine are Trm cells CD8 Trm cells persist for >1 year in transplanted duodenum Intraepithelial and lamina propria CD8 Trm cells show highly similar TCR repertoire Intestinal CD8 Trm cells efficiently produce cytokines and cytotoxic mediators