Titanacarborane Amide Catalyzed Transamination of Guanidines

This work describes a catalytic transamination of guanidines with a broad substrate scope of primary, secondary, heterocyclic, aliphatic, and aromatic amines, using 5−10 mol % of the half-sandwich titanacarborane amide [σ:η 1:η 5 -(OCH 2 )(Me 2 NCH 2 )C 2 B 9 H 9 ]Ti(NMe 2 ) as catalyst. This reaction tolerates common functional groups. The reaction mechanism is also proposed.