A patient with a clinical suspicion of pheochromocytoma was studied with MIBG labeled I-131. The patient had marked uptake of the radiopharmaceutical in the mediastinum, which was found to be the thymus gland at excisional biopsy. While interpreting I-131 MIBG imaging, possible MIBG uptake of normal thymic tissue must be considered to avoid a false-positive diagnosis of primary metastatic tumors.
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Ünal et al. (1995) studied this question.