Dapsone and renal papillary necrosis.

sistently ingested eight tablets (80 mg) daily without any side effects.Because he could not get metoclopramide without prescription while his regular doctor was away, he abruptly stopped taking the drug.Ten days later he progressively developed severe persistent facial dyskinesia consisting of repetitive involuntary movements of the lips, jaws, cheeks, and tongue.The latter were mainly constant, forceful sucking, chewing, grimacing, and rapid protrusions of the tongue.Results of general physical and neurological examinations were otherwise normal.Blood count, sedimentation rate, and biochemical and serological examinations showed nothing abnormal.The patient had never received other drugs known -to be associated with involuntary movements, such as phenothiazines or butyrophenones.Readministration of metoclopramide at a daily dose of 30 mg resulted in almost complete disappearance of the involuntary movements.Another attempt to withdraw the drug was associated with-recurrence of the dyskinesia, which subsided when metoclopramide was given again.