July 27, 2004Clinical Science

Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG

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Why the study?

Does probucol aggravate long QT syndrome in patients with the HERG M124T mutation?

Population

4 patients with long QT syndrome and a novel missense mutation M124T in the HERG gene, as well as Xenopus…

Design

Case_series

Follow-up

3 months (for the proband)

Authors

KHKenshi HayashiKanazawa University MSMasami ShimizuKyushu University HIHidekazu InoHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

May warrant caution with probucol in HERG M124T carriers; leaves open generalizability beyond this single case.

Structured PICO

Does probucol aggravate long QT syndrome in patients with the HERG M124T mutation?

Population

4 patients (a 59-year-old woman and 3 relatives) with long QT syndrome and a novel missense mutation M124T in the HERG gene, as well as Xenopus oocytes expressing wild-type and M124T mutant HERG channels.

Intervention

Probucol

Outcome

Electrophysiological properties of HERG channels (amplitude of HERG tail current, rate of channel activation and deactivation, reversal potential) and clinical occurrence of QT prolongation and torsade de pointes.surrogate

Probucol can aggravate long QT syndrome and induce torsade de pointes in patients with the HERG M124T mutation by further inhibiting the rapidly activating delayed rectifier K(+) current.

Cite This Study

Hayashi et al. (2004) studied this question.

synapsesocial.com/papers/6a910e8b5d48fdaeb8caf409 https://doi.org/10.1042/cs20030351

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Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider