Why the study?
Does magnesium infusion reduce mortality in patients with suspected acute myocardial infarction?
Does magnesium infusion reduce mortality in patients with suspected acute myocardial infarction?
The conclusion that magnesium provides no benefit in AMI based on pooled data using a fixed-effects model is controversial and has been questioned.
Magnesium (Mg) infusions over 24 hours were given to patients with suspected acute myocardial infarction (AMI) at least 2 hours after thrombolysis. Patients showed no benefit and even some increased risk in contrast to reduction in mortality obtained by Mg therapy in smaller trials. Results of all of the studies were pooled and statistically analyzed, according to a fixed-effects model that is inappropriate for studies of different protocols. The panel concluded that further study of Mg in AMI is not needed. This conclusion has been questioned.
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Mildred S. Seelig (2009) studied this question.
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