April 15, 2005Molecular TherapyOpen Access

Combined Genetic and Chemical Capsid Modifications Enable Flexible and Efficient De- and Retargeting of Adenovirus Vectors

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Population

Adenovirus vectors (preclinical model)

Design

Preclinical

Authors

FKFlorian KreppelWitten/Herdecke University JGJudith GackowskiRentschler Biopharma (Germany)ESErika SchmidtHochgebirgsklinik Davos

Discussion

Member takes

Implication

Supports retargeted adenoviral vectors in animal models; leaves open translation to human gene therapy.

Structured PICO

Population

Adenovirus vectors (preclinical model)

Intervention

Combined genetic (introduction of cysteines at solvent-exposed positions) and chemical (covalent coupling of ligands, amino-PEGylation) capsid modifications

Outcome

Targeting efficiency to specific pathways (e.g., transferrin receptor pathway)surrogate

A novel platform combining genetic and chemical modifications of adenovirus capsids enables flexible and efficient retargeting of viral vectors, with potential applications in clinical gene therapy and vaccination.

Cite This Study

Kreppel et al. (2005) studied this question.

synapsesocial.com/papers/6a9110cdc39ca0eda1830cfd https://doi.org/10.1016/j.ymthe.2005.03.006

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Combined Genetic and Chemical Capsid Modifications Enable Flexible and Efficient De- and Retargeting of Adenovirus Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Combined Genetic and Chemical Capsid Modifications Enable Flexible and Efficient De- and Retargeting of Adenovirus Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider