Size monodisperse restricted-access and permeable polymer-based separation media were prepared and utilized as HPLC packing materials for void volume recovery of polypeptides and chromatographic separation of drugs. Restricted-access polymer-based packing material gave quantitative recovery of the polypeptide, but separation of some drugs was very poor, while permeable packing material with sufficiently large pores showed good recovery of the polypeptide and also excellent separation of the drugs.
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Hosoya et al. (1993) studied this question.
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