Hemophilia, Hepatitis, and the Acquired Immunodeficiency Syndrome

Editorials1 March 1983Hemophilia, Hepatitis, and the Acquired Immunodeficiency SyndromeGILBERT C. WHITE II, M.D., HENRY R. LESESNE, M.D.GILBERT C. WHITE II, M.D.Search for more papers by this author, HENRY R. LESESNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-403 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPreparations of blood fractions for transfusion contain various infectious agents that may be transmitted to the recipient. Cytomegalovirus, hepatitis B virus, and non-A, non-B viruses are among the many agents that may be contained in these fractions. The risk of infection with these agents is increased in patients with hemophilia who receive concentrates of plasma derived from many donors and who receive such concentrates on repeated occasions. Approximately 85% of patients with clinically severe hemophilia needing frequent transfusions with concentrates of factor VIII or IX have serologic evidence of previous exposure to hepatitis B antigen (HBsAg), and up to 10%...References1. CEDERBAUMBLATTLEVINE APP. Abnormal serum transaminase levels in patients with hemophilia A. Arch Intern Med. 1982;142:481-4. CrossrefMedlineGoogle Scholar2. LESESNEMORGANBLATTWEBSTERROBERTS HJPWH. Liver biopsy in hemophilia A. Ann Intern Med. 1977;86:703-7. LinkGoogle Scholar3. SPEROLEWISVAN THIELHASIBARABIN JJDUB. Asymptomatic structural liver disease in hemophilia. N Engl J Med. 1978;298:1373-8. CrossrefMedlineGoogle Scholar4. WHITEZEITLERLESESNE GKH. Chronic hepatitis in patients with hemophilia A: histologic studies in patients with intermittently abnormal liver function tests. Blood. 1982;60:1259-62. MedlineGoogle Scholar5. . Pneumocystis carinii pneumonia among persons with hemophilia A. Morbid Mortal Weekly Rep. 1982;31:365-7. 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Author, Article, and Disclosure InformationAffiliations: University of North Carolina Chapel Hill, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfectious Agents Transmitted by TransfusionComplications in HIV-infected and non-HIV-infected haemophiliacs and other patients after oral surgeryPrimary wound closure in haemophiliacs undergoing dental extractionsFunctional studies of cell-mediated immunity in haemophilia and other bleeding disordersDDAVP and EACA used for minor oral surgery in von Willebrand diseaseAcquired Immunodeficiency Syndrome (AIDS)Frequent lymphocytes infection by hepatitis B virus in haemophiliacsFrequent lymphocytes infection by hepatitis B virus in haemophiliacsHepatitis B vaccination of 113 hemophiliacs: Lower antibody response in anti-LAV/HTLV-III-positive patientsSmall-Pool High-Yield Factor VIII ProductionCholinesterase Phenotyping: Clinical Aspects and Laboratory ApplicationsA study of lymphocyte populations and subpopulations in hemophiliacs and their relationships with age and consumption of lyophilized factor VIII concentratesTRANSMISSION OF NON-A, NON-B HEPATITIS BY HEAT-TREATED FACTOR VIII CONCENTRATERelationships between blood product exposure and immunological abnormalities in English haemophiliacsSide Effects of Substitution TherapyAcquired Immunodeficiency Syndrome (AIDS) in HemophiliacsThe significance of AIDS to dentists and dental practiceAbnormalities of lymphocyte subsets are correlated with concentrate consumption in asymptomatic Italian hemophiliacs treated with concentrates made from American plasmaUNREGULATED PRODUCTION OF VIRUS AND/OR SPERM SPECIFIC ANTI-IDIOTYPIC ANTIBODIES AS A CAUSE OF AIDSAbnormal T-Lymphocyte Subsets in Hemophilia: Relation to HLA Proteins in Plasma ProductsThe Acquired Immunodeficiency Syndrome in Patients with HemophiliaBRUCE L. EVATT, M.D., ROSEMARY B. RAMSEY, M.S., DALE N. LAWRENCE, M.D., LAWRENCE D. ZYLA, M.P.H., JAMES W. CURRAN, M.D.Nosocomial acquired immunodeficiency syndrome and human T-cell leukaemia lymphoma virus associated diseaseEvidence that less replacement therapy is required for dental extractions in hemophiliacsAcquired Immune Deficiency SyndromeSystemic Cryptococcal Infection in HomosexualCharacteristics of the Acquired Immunodeficiency Syndrome (AIDS) in HaitiAntibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in HemophiliacsAcquired immune deficiency syndromeIMPACT OF CHLORAMPHENICOL USE ON BACTERIAL RESISTANCE IN A NEONATAL INTENSIVE CARE UNITPLASMA FRACTIONATION METHODS AND T-CELL SUBSETS IN HAEMOPHILIAPOSSIBLE IMPLICATIONS OF THE EFFECT OF BLOOD TRANSFUSION ON ALLOGRAFT SURVIVAL 1 March 1983Volume 98, Issue 3Page: 403-404KeywordsAIDSAntigensBlood plasmaBlood transfusionHemophiliaHepatitisHepatitis BHepatitis B virusInfectious hepatitis ePublished: 1 December 2008 Issue Published: 1 March 1983 PDF downloadLoading ...