This case highlights the rare but severe long-term complication of radiation-induced angiosarcomatosis decades after radiotherapy for cervical cancer.
Raises awareness for late radiation-induced angiosarcomatosis in cervical cancer survivors; leaves open incidence, risk factors, and surveillance needs.
BACKGROUND: We report a case of a 61-year-old Japanese woman who developed intra-abdominal angiosarcomatosis 20 years after receiving radiotherapy for squamous cell carcinoma of the cervix. METHODS AND RESULTS: The surgically resected portion of the ileum showed diffuse proliferating angiosarcoma, with irregular channels lined by atypical vascular endothelial cells. Immunohistochemical studies showed that the tumour cells were positive for Factor VIII-related antigen and ulex europaeus agglutinin 1. At autopsy, the tumour had disseminated to the peritoneum and invaded into the right thoracic cavity. CONCLUSIONS: These findings were compatible with radiation-induced angiosarcomatosis.
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Suzuki et al. (1999) studied this question.
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