Serologically reactive substances (“soluble antigens”) which were readily detectable by precipitation and by complement fixation with Cryptococcus antiserum were found in the spinal fluid, blood serum? and urine of a patient with cryptococcal meningitis. Absorption of the antiserum with solutions of purified Cryptococcus polysaccharide removed its capacity to react with the fluids of the patient. The reactive substances in the patient's fluids were relatively heat stable and it is probable that they represent capsular polysaccharides of the fungus with which the patient was infected.
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Neill et al. (1951) studied this question.