Design of a G‐Quadruplex Topology through Glycosidic Bond Angles

Building regulations: Thus far the discovery of novel DNA quadruplex topologies was either serendipitous or through coincidental emergence. Now a deductive system, based on the glycosidic bond angle of guanosines, can be used to derive a set of inference rules for the prediction of both known and theoretical quadruplex topologies. This formalism was used to design and control the self-assembly of a novel DNA quadruplex architecture.