Recurrent interface infiltration with hypopyon after astigmatic laser in situ keratomileusis on a penetrating corneal graft

A 56-year-old woman was referred with recurrent interface infiltration and hypopyon after astigmatic laser in situ keratomileusis (LASIK) on a corneal graft. Pseudomonas aeruginosa was isolated as the causative pathogen. Penetrating keratoplasty had been performed 2 years before refractive surgery. After the antibiotic medication was tapered, 3 recurrences of interface infiltration with hypopyon were observed. Penetrating rekeratoplasty was deemed appropriate. Histological examination of the explanted corneal graft revealed anterior stromal neutrophil infiltration. This case illustrates that microbial pathogens brought underneath the flap by LASIK can persist months later despite antimicrobial treatment.