Why the study?
Does sodium depletion alter the levels of active and inactive renin in dog kidneys and plasma?
Does sodium depletion alter the levels of active and inactive renin in dog kidneys and plasma?
Sodium depletion significantly increases both active and inactive renin in dog kidneys and plasma, suggesting plasma inactive renin originates at least partly in the kidney.
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Should not change human hypertension management; supports renal origin of plasma inactive renin in dogs.
Akabane et al. (1984) studied this question.
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