La Crosse virus (LAC) is a member of the California encephalitis serogroup of the insect-transmitted bunyavirus family. These viruses grow in both insect and animal cells, but the fate of the infection is dramatically different depending on the species. The natural host for LAC is the mosquito Aedes triseriatus. In mosquitoes or in mosquito cells in culture, the viral infection is asymptomatic, whereas in mammals or mammalian cells in culture, the viral infection is associated with cytopathic effects. The genome of these viruses consists of three segments of single-stranded RNA of negative polarity, each contained within a separate nucleocapsid (NC), which are labeled small (S), medium (M), and large (L). The viral NCs have helical symmetry and appear in the electron microscope as circular and super-coiled structures (Obijeski et al. 1976).
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Kolakofsky et al. (1987) studied this question.
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