Effective Oxidation of 5‐Hydroxymethylfurfural to 2,5‐Diformylfuran by an Acetal Protection Strategy

An acetal protection strategy for 5‐hydroxymethylfurfural (HMF) was used to obtain 2,5‐diformyfuran (DFF) using concentrated HMF solutions and a γ‐Al2O3‐supported Ru catalyst (Ru/γ‐Al2O3). The HMF‐acetal with 1,3‐propanediol can be oxidized to DFF‐acetal with a yield of 84.0 % at an HMF conversion of 94.2 % from a 50 wt % solution. In contrast, aerobic oxidation of nonprotected HMF using a 10 wt % solution afforded DFF only in a moderate yield (52.3 %). Kinetic studies indicated that the six‐membered ring acetal group not only prevents side reactions but also accelerates aerobic oxidation of the −CH2OH moiety to −CHO under retention of the acetal functionality. Organic deposits formed during the reaction explained the significant decrease in the activity of the Ru/γ‐Al2O3 catalyst, which could be recovered neither by washing in water or organic solvents, nor by a calcination‐reduction treatment. Sonication of the used Ru/γ‐Al2O3 catalyst in an aqueous NaOH solution successfully removed the deposits and allowed reuse of the catalyst for at least four times without activity loss.