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The complications of paranasal sinus infection in infants and young children are numerous. Acute suppurative paranasal sinus disease and acute suppurative otitis media go together. Numerous ocular conditions, phlyctenular conjunctivitis, iritis, retrobulbar neuritis and choroiditis are usually benefited by the treatment of the coexistent paranasal sinus disease. Dr. McCullough of New York has seen three cases of retrobulbar neuritis secondary to paranasal sinus disease in children under 14 years of age. Dr. White of Boston, recalls several cases of involvement of the optic nerve of children 5 years of age and older. Dr. Gregg of Sioux Falls had a similar case in a child, aged 8 years. There may be an interdependence between chronic multiple infectious arthritis and paranasal sinus disease in infants and young children. The absorption of bacterial protein from an infection of the sinus may be an etiologic factor in the causation of asthma in childhood. In
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L. W. Dean (1925) studied this question.
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