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October 1, 2021Journal of Pediatrics ReviewOpen Access

Genetics of Legg-Calvé-Perthes Disease: A Review Study

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Why the study?

The etiology of Legg-Calve-Perthes Disease is complex and involves genetic factors, prompting a review to summarize current knowledge on the role of genetic variants in its incidence.

Design

Review study

Authors

SASamira AsadollahiHNHossein NeámatzadehNNNasim Namiranian

Discussion

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Overview

Genetic variants may influence LCPD risk; leaves open validation before informing pediatric screening or management.

Structured PICO

P
Population
Patients with Legg-Calvé-Perthes Disease (LCPD) or juvenile hip disorders
I
Intervention
Evaluation of genetic variants (mutations in thrombophilia factors, COL2A1, TRPS1, eNOS genes)
O
Outcome
Role of genetic variants in the incidence of LCPD

Genetic testing may aid in the diagnosis and management of Legg-Calvé-Perthes Disease by identifying underlying mutations such as those in thrombophilia factors and specific genes.

Cite This Study

Asadollahi et al. (2021) studied this question.

synapsesocial.com/papers/6a9128cf32ba294847c64eefhttps://doi.org/10.32598/jpr.9.4.964.1
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prothrombin complex concentrate for vitamin K antagonist reversal in acute bleeding settings: efficacy and safety2019 · 4 citations
  2. 2SUMOylation modulates transcriptional repression by TRPS12007 · 20 citations
  3. 3Legg-Calvé-Perthes Disease2010 · 132 citations