An attempt was made to improve the dissolution rate of disopyramide, which is a slightly soluble drug, by the preparation of solid dispersion systems with polyvinylpyrrolidone and γ-cyclodextrin. The resulting solid dispersion systems were examined by the phase solubility method, differential scanning calorimetry and X-ray diffractometry. The dissolution rates of the drug from these aolid dispersion systems were greater than that of intact dispyramide.
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Takahashi et al. (1988) studied this question.
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