Poorly-Differentiated Endocrine Carcinomas of Midgut and Hindgut Origin

last decades; from SEER cancer database colonic carcinoids are uncommon with a rather constant incidence [2] .These trends may relate to an increased awareness about rectal carcinoids and an increased number of diagnostic examinations and endoscopic polypectomies.In western Sweden, the number of patients with clinically diagnosed rectal carcinoids were studied over three decades (1959-1988) showing a rising trend with 11, 21 and 37 cases per decade -only 1 patient had metastatic disease [5] .In contrast, during a recent 5-year period (2000)(2001)(2002)(2003)(2004)(2005) 7 patients with PDEC tumors of the colon and rectum were diagnosed in the same geographical region.These figures indicate that PDEC may have been misdiagnosed as adenocarcinoma prior to the publication of the WHO 2000 criteria [6] .Two histological types of PDEC of the gastrointestinal tract can be identified: small or large cell carcinomas [6] .A nationwide SEER study on rare tumors of colon and rectum from the USA showed