Papillomas of the Larynx with Intraepithelial Anaplastic Changes

In preceding papers the clinical and histological characteristics of cancer in situ of the larynx were discussed.*Papillomas with anaplastic changes in the epithelium were at that time purposely omitted from the discussion because it had been felt that they deserved a special study. In an attempt to carry out such an investigation, all the papillomas of the larynx were reviewed which had been seen and treated at the Department of Otolaryngology, Presbyterian Hospital in the City of New York, during a period of 15 years (1939-1953). Only adult patients were dealt with, and the total number of cases observed was 51. Both single and multiple papillomas were reviewed; the relative frequency of the two types, as well as their sex distribution, can be found in Table 1. There is practically no difference between sexes, 28 men and 23 women being affected, but there is a marked difference in the