September 10, 2018BioMed Research InternationalOpen Access

Atrial Structural Remodeling Gene Variants in Patients with Atrial Fibrillation

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Population

94 patients with atrial fibrillation (76 with atrial dilatation and 18 without)

Design

Cross-sectional

Authors

RPRosa Doñate PuertasInserm GMGilles MillatUniversité Claude Bernard Lyon 1 IEIsabelle ErnensLuxembourg Institute of Health

Discussion

Member takes

Implication

May support NGS screening for structural variants in AF; leaves open functional validation before clinical adoption.

Structured PICO

Population

94 patients with atrial fibrillation (76 with atrial dilatation and 18 without)

Intervention

High-throughput next-generation sequencing (NGS) using a custom AmpliSeq panel of 55 genes potentially involved in atrial myopathy

Outcome

Identification of potentially pathogenic rare variants in genes involved in atrial tissue structural remodelingsurrogate

A custom NGS panel identified 11 novel potentially pathogenic genetic variants associated with atrial structural remodeling in patients with AF, particularly those with atrial dilatation.

Limitations

Functional studies are needed to confirm pathogenicity

Cite This Study

Puertas et al. (2018) studied this question.

synapsesocial.com/papers/6a912c342d14ef2b6ea15154 https://doi.org/10.1155/2018/4862480

Topics

Atrial fibrillation Persistent AF management

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