Thrombo-Angiitis Obliterans: A Clinical Study of 200 Cases

Article1 February 1928Thrombo-Angiitis Obliterans: A Clinical Study of 200 CasesI. Etiology, Pathology, Symptoms, DiagnosisEDGAR V. ALLEN, M.D., GEORGE E. BROWN, M.D.EDGAR V. ALLEN, M.D.Search for more papers by this author, GEORGE E. BROWN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-8-535 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous gangrene of the feet in middle-aged patients without arteriosclerosis has been known for many years. In 1879 Winiwarter reported the case of a man, aged fifty-seven, who had complained of rheumatic pains in the feet for twelve years. The pathologic changes were intimal proliferation, thrombosis and periarterial fibrosis; arteriosclerosis was absent. He designated the condition as a peculiar type of endarteritis and endophlebitis. Weiss, in 1895, and Manteuffel, in 1897, reported similar cases from which they concluded that the thrombosis was due to intimal changes of an arteriosclerotic nature. In 1879 Borchard reported five cases and favored the view...Bibliography(1) ALLENBROWN EVGE: Four cases of atypical vascular disease affecting the extremities. Med. Clin. N. Amer., 1926, x, 611-624. Google Scholar(2) ALLENBROWN EVGE: Erroneous diagnosis of Raynaud's disease in obliterative vascular disease (thrombo-angiitis obliterans). I. Vasomotor disturbances simulating Raynaud's disease. Am. Jour. Med. Sc., 1927, clxxiv, 319-329. CrossrefGoogle Scholar(3) ALLENBROWN EVGE: Erroneous diagnosis of Raynaud's disease in obliterative vascular disease (thrombo-angiitis obliterans). II. Thrombo-angiitis obliterans of the lower extremities with pulsating pedal arteries. Am. Jour. Med. Sc., 1927, clxxiv, 329-337. Google Scholar(4) BENEDICTVON LACKUMNICKEL WLWHAC: The pelvic organs as foci of infection in inflammatory diseases of the eye. Tr. Am. Ophth. Soc., 1927, lvi, 116-123. Google Scholar(5) BORCHARDS Beiträge zur primären Endarteritis obliterans. Deutsch. Ztschr. f. Chir., 1897, xliv, 131-178. CrossrefGoogle Scholar(6) BROWN GE: The treatment of peripheral vascular disturbances of the extremities. Jour. Am. Med. Assn., 1926, lxxxvii, 379-383. CrossrefGoogle Scholar(7) BUERGER L: Thrombo-angiitis obliterans: a study of the vascular lesions leading to presenile spontaneous gangrene. Am. Jour. Med. Sc., 1908, cxxxvi, 567-580. CrossrefGoogle Scholar(8) BUERGER L: The veins in thrombo-angiitis obliterans. Jour. Am. Med. Assn., 1909, lii, 1319-1324. CrossrefGoogle Scholar(9) BUERGER L: The pathology of thrombo-angiitis obliterans. Med. Rec., 1920, xcvii, 431-437. Google Scholar(10) BUERGERKALISKI LD: Complement-fixation tests in thrombo-angiitis obliterans. Med. Rec., 1910, lxxviii, 665-669. Google Scholar(11) BUNGE : Quoted by Buerger, 1908. Google Scholar(12) CHLUMSKY V: Uber Phlebitis chronica Migrans. Zentralbl. f. d. ges. Kinderheilk, 1927, ii, 75-77. Google Scholar(13) CONSTAM GR: Primary involvement of the upper extremities in thrombo-angiitis obliterans (Buerger's disease). Am. Jour. Med. Sc., 1927, clxxiv, 530-536. CrossrefGoogle Scholar(14) GEMMILL WF: Thrombo-angiitis obliterans. Atlantic Med. Jour., 1926, xxix, 244-245. Google Scholar(15) GOODMANBERNSTEIN CEP: Presenile gangrene-thrombo-angiitis obliterans. New York Med. Jour., 1916, ciii, 1073-1074. Google Scholar(16) ITO : Rinige chirurgische Krankheiten welche in Japan haeufiger Vorkommen als in Europa und umgekehrt. Congres International de Medicine. Compt. rend. Chir., Budapest, 1910, vii, 499. Google Scholar(17) KOGA G: Zur Therapie der Spontangangrän an den Extremitäten. Deutsch. Ztschr. f. Chir., 1913, cxxi, 371-382. CrossrefGoogle Scholar(18) KOYANO K: A clinical study of one hundred twenty cases of thrombo-angiitis obliterans among the Japanese. Scholae Med. Univ. Imp., Kioto, 1921-1922, iv, 489-499. Google Scholar(19) LUDLOW : Four cases of thrombo-angiitis obliterans (Korean cases). China Med. Jour., 1920, xxxiv, 18. Google Scholar(20) MANTEUFFEL : Quoted by Buerger, 1908. Google Scholar(21) MELENEYMILLER FLCG: A contribution to the study of thrombo-angiitis obliterans. Ann. Surg., 1925, lxxxi, 976-993. CrossrefGoogle Scholar(22) MEYER W: The etiology of thrombo-angiitis obliterans. Med. Rec., 1919, xcv, 901. Google Scholar(23) MEYER W: A further contribution to the etiology of thrombo-angiitis obliterans. Med. Rec., 1920, xcvii, 425-430. Google Scholar(24) MULLER LR: Studien über den Dermographismus and dessen diagnostische Bedeutung, Deutsch. Ztschr. f. Nervenh., 1913, xlvii-xlviii, 413-434. CrossrefGoogle Scholar(25) OCHSNER AJ: Discussion. Surg., Gynec. and Obst., 1915, xxi, 536. Google Scholar(26) PERLA D: An analysis of forty-one cases of thrombo-angiitis obliterans. Surg., Gynec. and Obst., 1925, xli, 21-30. Google Scholar(27) RABINOWITZ MM: Experiments on the infectious origin of thrombo-angiitis obliterans and the isolation of a specific organism from the blood stream. Surg., Gynec. and Obst., 1923, xxxvii, 353-360. Google Scholar(28) ROSENOWNICKEL ECAC: Unpublished data of work done in conjunction with the authors. Google Scholar(29) STEEL WA: Intravenous citrate of soda treatment of thrombo-angiitis obliterans (Buerger's disease). Med. Rec., 1921, xcix, 370. Google Scholar(30) TODYO T: Beiträg zur Pathogenese der sagenannten spontanen Gangrän. Arch. f. klin. Chir., 1912, xcvii, 640-685. Google Scholar(31) WEISS : Quoted by Buerger, 1908. Google Scholar(32) WHYTE : Thrombo-angiitis obliterans in China. China Med. Jour., 1920, xxxiv, 371-378. Google Scholar(33) WIETING : Die angiosklerotische Gangrän und ihre operative Behandlung durch arteriovenöse Intubation. Deutsch. med. Wchnschr., 1908, ii, 1217-1221. Google Scholar(34) WINIWARTER F: Ueber eine eigenthumliche Form von Endarteriitis und Endophlebitis mit Gangrän des Fusses. Arch. f. klin. Chir., 1879, xxiii, 202-226. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Mayo FoundationDivision of Medicine Mayo Clinic Rochester, Minnesota*Submitted for publication January 24, 1928.*Three hundred cases will be reported in detail in the form of a monograph at a later date. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Management of Ischemic Limb in Thromboangiitis Obliterans (Buerger’s Disease)JCS 2017 Guideline on Management of Vasculitis Syndrome ― Digest Version ―A haplotype of Toll-like receptor 1 is associated with resistance to Buerger disease in JapaneseThromboangiitis ObliteransThromboangiitis Obliterans (Buerger's Disease)Thromboangiitis Obliterans (Buerger’s Disease)—Current PracticesAre There Any Objections against Our Hypothesis That Buerger Disease Is an Infectious Disease?Guideline for Management of Vasculitis Syndrome (JCS 2008) - Digest Version -Thromboangiitis ObliteransPeriodontal bacteremia and various vascular diseasesAssociation between periodontitis and anti-cardiolipin antibodies in Buerger diseasePeriodontitis and cardiovascular diseases: The link and relevant mechanismsBuerger Disease, Smoking, and PeriodontitisElevated IgG titers to periodontal pathogens related to Buerger diseaseThromboangiitis Obliterans (Buerger's Disease)A rational basis for management of patients with the Buerger syndromeOral bacteria in the occluded arteries of patients with Buerger diseaseImplantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease)Has the clinical definition of thromboangiitis obliterans changed indeed?Angiologische DiagnostikRaynaud’s syndromeBuerger's Disease: Current StatusAcute and Chronic Upper Extremity Ischemia. II. Small Vessel Arterial Occlusive DiseaseBuerger's Disease (Thromboangiitis Obliterans)Buerger's disease in the modern eraBuerger’s Disease RevisitedA Critical Evaluation of Thromboangiitis ObliteransKrankheiten der GefäßeThe Clinical Significance of Raynaud's Phenomenon and Raynaud's DiseaseChronisch entz�ndliche Gef��erkrankungen und deren Auswirkungen auf die HautCutaneous Manifestations of Some Common Peripheral Vascular Diseases 1 February 1928Volume 1, Issue 8Page: 535-549KeywordsFibrosisRheumatic painThrombosis Issue Published: 1 February 1928 PDF DownloadLoading ...