Why the study?
Does heparin anticoagulant therapy prevent thromboembolic complications in a pregnant patient with Kawasaki disease and coronary aneurysms?
Does heparin anticoagulant therapy prevent thromboembolic complications in a pregnant patient with Kawasaki disease and coronary aneurysms?
Heparin anticoagulant therapy can be safely and effectively used to prevent thromboembolic complications during pregnancy and delivery in a patient with Kawasaki disease and severe coronary artery involvement.
Supports heparin anticoagulation in this rare case; hypothesis-generating and requires confirmation before practice change.
Thirty-one-year-old woman with Kawasaki disease wanted a child. She had a large coronary aneurysm on the left main coronary artery and complete obstruction of the right coronary artery, but there was no sign of ischemia. Heparin anticoagulant therapy was begun 8 weeks after the onset of pregnancy. The activated partial thromboplastin time (APTT) was successfully maintained at 1.5 to 2.0 times normal value during pregnancy and puerperium. There were no thromboembolic complications during pregnancy or after an uneventful cesarean delivery. The neonate was healthy.
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Arakawa et al. (1997) studied this question.
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