Why the study?
Does alteration of the adreno-testes equilibrium affect susceptibility to experimental poliomyelitis in Syrian hamsters?
Does alteration of the adreno-testes equilibrium affect susceptibility to experimental poliomyelitis in Syrian hamsters?
This preclinical study demonstrates that hormonal interactions, specifically the adreno-testes equilibrium, significantly influence the susceptibility of Syrian hamsters to experimental poliomyelitis.
Answers are grounded in this paper and cite their sources.
Endocrine balance modulates viral susceptibility in hamsters; leaves open human relevance and requires prospective validation.
Alterations in susceptibility of the Syrian hamster to poliomyelitis virus (MEF1) inoculated intracerebrally appeared closely related to seasonal changes and experimental disturbances in the adreno-testes equilibrium. Enhanced susceptibility coincided with seasonal enlargement of adrenals, followed cortisone and DOCA treatment and appeared during the initial postorchiectomy period. Increased resistance occurred incidentally to adrenalectomy, seasonal diminution in adrenal weight, testosterone overdosage, and testicular hypertrophy induced by treatment with GTH or chorionic gonadotrophin. The effect of certain hormonal interactions, the interference of conditioning factors and the role of compensatory reactions are discussed.
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Teodoru et al. (1954) studied this question.
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