Recent Progress in the Quinoline Chemistry. Synthesis and Biological Activity

This review describes the synthesis and screening data of quinoxaline derivatives mainly reported in the last few years.This review involves the following contents.I. Introduction 11.Synthesis of Quinoxalines Utilizing Aryl Diazonium Salts 1. 3-(a-Arylhydrazono)heteroarylmethyl-2-oxo-l,2-dihydoquinoxlines and l-Aryl-3-quinoxalinyl-1,2,4-triazol-5-ones 2. l-Aryl-l~-pyrazolo[3.4-~]quinoxalines 3 .l-Aryl-3-heteroaryl-1~-pyra~olo[3,4-blquinoxa1ines 4. Pyridazino[3,4-b]quinoxalines 5 .3-Quinaxalinylpyrazolo[5,1-~l,2,4]triazines 111.Synthesis of 3-Quinoxalinyl-1,2,4-tria~010[3,4-f][1,2,4]triazines IV.Synthesis of Quinoxalines Aiming at Melanine Biosynthesis Inhibitor 1. P y r i d o [ 3 , 2 , 1 -i , i ] q u i n o x a l i n e s and Pyrrola[3,2,1-i,i]quinoxalines 2. Tetrazolo[l,S-alquinoxalines and Triazolo[4,3-a]quinoxalines V .Synthesis of 2-PyridazinylquinoxaLines Aiming at Carotenoid Biosynthesis Inhibitor VI.Synthesis of 2-(Dinitratrifluoromethylani1ino)quinoxaline Aiming a t Anti-fungal Agent VII.Successful Development of A New Herbicide Quizalofop-Et 1. Synthesis of Quizalofop-Et and Related Compounds 2. Synthesis of Fluorinated Quizalofop-Et and Related Compounds