February 1, 2001Journal of Hypertension
Angiotensin converting enzyme protects acetylcholine-induced relaxation from its attenuation by formyl-methionyl-leucyl-phenylalanine in rat aorta
Structured PICO
P
Population
Aortic rings from 9-week-old Sprague-Dawley rats
I
Intervention
Angiotensin converting enzyme (ACE), captopril, and/or formyl-methionyl-leucyl-phenylalanine (fMLP), with or without dexamethasone treatment
C
Comparator
Control aortas
O
Outcome
Acetylcholine (ACh)-induced relaxation (maximal relaxation, Emax)surrogate
Endothelial-cell ACE protects against the attenuation of acetylcholine-induced vasorelaxation by fMLP, likely through its cleavage.
Authors
Discussion
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Implication
ACE may protect endothelial vasorelaxation from fMLP in this model; leaves open relevance to human hypertension.
Cite This Study
Ando et al. (2001) studied this question.