Primary Structural Differences in Myeloma Proteins That Bind the Same Haptens

In this paper, we present new and recently published amino acid sequences of antigen-binding myeloma proteins of BALB/c origin, with specificity for phosphorylcholine (PC), inulin, and β-l,6, 6 d-galactan. The origin and source of these and other related myeloma proteins are given in Table 1. As can be seen, with the exception of CBPC-2 and CBPC-4, which were derived from plasmacytomas induced in the immunoglobulin (Ig)-congenic C.B/20 mouse (BALB/c mouse carrying IgCH-VH loci of C57BL/ka origin), all the myeloma proteins were derived from tumors induced in BALB/c mice by mineral oils and related substances (see Potter 1972). In each group, there are eight or more proteins.