A mixture of different conformers of the flexible tetrasaccharide sialyl Lewisx is presented in solution to the E-selectin receptor, which binds only one conformation, as shown by NMR spectroscopy. The experimentally determined transfer NOEs can be used to derive proton–proton distance restrictions, which together with the confomer ensemble obtained by Metropolis Monte Carlo simulations, can be used to determine the conformation of sialyl Lewisx in the complexed state.
No takes yet. Share an insight, caveat, or question.
Peters et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: