Further Observations on the Mechanism of Ulcer Pain

Article1 December 1959FURTHER OBSERVATIONS ON THE MECHANISM OF ULCER PAINE. CLINTON TEXTER JR., M.D., F.A.C.P., GASTON R. VANTRAPPEN, M.D., HAROLD P. LAZAR, M.D., ERNESTO J. PULETTI, M.D., CLIFFORD J. BARBORKA, M.D., F.A.C.P.E. CLINTON TEXTER JR., M.D., F.A.C.P.Search for more papers by this author, GASTON R. VANTRAPPEN, M.D.Search for more papers by this author, HAROLD P. LAZAR, M.D.Search for more papers by this author, ERNESTO J. PULETTI, M.D.Search for more papers by this author, CLIFFORD J. BARBORKA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1275 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDirect chemical irritation by hydrochloric acid and disordered motor activity of the stomach and duodenum have been implicated in the causation of ulcer pain. The presence or absence of vascular engorgement of the mucosa in the region of the ulcer has also been related to ulcer pain. Many investigators have tended to support one or the other points of view without implicating other factors. Although the concept of direct chemical irritation has been the more commonly accepted one among gastroenterologists, physiologists have maintained that the mechanism for pain arising from any of the hollow viscera is some disorder of motor...Bibliography1. Prout W: On the nature of the acid and saline matters usually existing in the stomach of animals, Phil. Tr. Roy. Soc. London 144: 45, 1824. Google Scholar2. Davies RE: The metabolism of the acid-secreting stomach, Am. J. Digest. Dis., N. S. 4: 173, 1959. CrossrefMedlineGoogle Scholar3. Bonninger M: Zur Diagnoses des Ulcus ventriculi, Berl. klin. Wchnschr. 45: 396, 1908. Google Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication May 12, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the Gastroenterology Unit, Department of Medicine, Veterans Administration Research Hospital, Passavant Memorial Hospital, and Northwestern University Medical Center, Chicago, Illinois.†This investigation was supported by grants from the John and Mary R. Markle Foundation, the Smith, Kline and French Foundation, the Lakeland Foundation, the James Picker Foundation, the National Institutes of Health, U. S. Public Health Service (RG 4633-C2 Physiology and 2A-5094-C1 National Institute of Arthritis and Metabolic Diseases), G. D. Searle and Company, A. H. Robins Company, and the Gastroenterology Research Fund.‡With the technical assistance of (Mrs.) JUNKO MIZUTA, B.S., Chicago, Illinois.Requests for reprints should be addressed to E. Clinton Texter, Jr., M.D., Assistant Professor of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago 11, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypersenstivity to Acid in Ulcer-Like Functional DyspepsiaBlocked and nonblocked acid secretion and reported pain in ulcer, nonulcer dyspepsia, and normal subjectsUlcer Pain Mechanisms the Clinical Features of Active Peptic Ulcer Disease and Implications for TherapyAcid perfusion of duodenal ulcer craters and ulcer pain: a controlled double blind study.Pain experience and acid secretion in gastrointestinal disorders: A comparison of ulcer and nud patientsPain in Peptic UlcerMagenbeschwerden ohne organischen BefundFluorocinematography 1 December 1959Volume 51, Issue 6Page: 1275-1294KeywordsGastric ulcersGastroenterology and hepatologyHospital medicineHydrochloric acidMucous membranesPeptic ulcersPrevention, policy, and public healthResearch fundingStomachUlcers ePublished: 1 December 2008 Issue Published: 1 December 1959 PDF downloadLoading ...