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Serum and urine osmolality values for 250 pregnant and nonpregnant Nigerian women were determined with an Advanced Laboratory Osmometer. There was a statistically significant difference in the serum and urine osmolality of nonpregnant and pregnant women. There was a fall of about 11 mOsm/kg in serum osmolality in pregnancy, but this was not thought to be due to sodium loss because there was no significant difference in sodium concentration in the nonpregnant and pregnant women. No significant correlation was found between serum and urine osmolality in the two groups of women.
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Agboola et al. (1978) studied this question.
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