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May 1, 1996Blood

Single-chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1

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Authors

AHAA HigaziHospital of the University of PennsylvaniaAMAndrew P. MazarIo Therapeutics (United States)JWJ WangNorthwestern University

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Higazi et al. (1996) studied this question.

synapsesocial.com/papers/6a913a29cdcb4f7bdda152dahttps://doi.org/10.1182/blood.v87.9.3545.bloodjournal8793545
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor1995 · 101 citations
  2. 2Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin.1985 · 133 citations
  3. 3Plasminogen Activator Inhibitors - A Review2017 · 293 citations
  4. 4Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes1991 · 108 citations
  5. 5Characterization of the Binding of Urokinase‐type Plasminogen Activator (u‐PA) to Plasminogen, to Plasminogen‐activator Inhibitor‐1 and to the u‐PA Receptor1994 · 23 citations