Why the study?
Does Roux-en-Y gastric bypass reduce aortic wall thickness in Zucker diabetic fatty rats?
Does Roux-en-Y gastric bypass reduce aortic wall thickness in Zucker diabetic fatty rats?
Roux-en-Y gastric bypass reduces aortic wall thickness in a diabetic rat model, potentially mediated by elevated bile acids and L-PGDS.
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May indicate vascular protection from RYGB in diabetic rat models; leaves open human translation and mechanisms.
BACKGROUND: Roux-en-Y gastric bypass (RYGB) may improve cardiometabolic risk through alteration of bile acids and L-PGDS levels. OBJECTIVE: The objective of this study was to investigate the effect of RYGB on aortic wall thickness, in relation to bile acid and L-PGDS metabolism. METHODS: Zucker diabetic fatty (ZDF) rats were divided into two groups, ad lib (n = 4), and RYGB (n = 6). Bile acid and L-PGDS were measured presurgery and fourteen weeks post-surgery. RESULTS: Elevation of bile acid levels following RYGB in Zucker Diabetic Fatty (ZDF) rodents was observed, as compared to ad lib. RYGB in ZDF rodents led to a significantly decreased aortic wall thickness (25%) as compared to ad lib control. Although bile acid metabolism is implicated in these alterations, other mediators are likely involved. Our laboratory has demonstrated lipocalin prostaglandin D2 synthase (L-PGDS) is a kno n cardiometabolic modulator that also functions as a bile acid binding protein. Therefore, L-PGDS levels were measured and a significant elevation was observed with RYGB compared to ad lib control. CONCLUSION: Based on these findings, RYGB showed beneficial effect on aortic wall thickness, possibly through bile acids and L-PGDS elevation in a severely obese and diabetic rodent model.
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Kumar et al. (2015) studied this question.
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