The response of the sweat glands to βT-adrenergic stimulation with isoprenaline

Sweat responses were obtained in fifteen out of eighteen subjects, using local injections of different concentrations of isoprenaline. In the majority of these subjects injections of 10 ‐3 mg in o.1 ml were the most effective. The sweat response could not be re‐induced at the same site. No sweat responses could be obtained from sites which had been previously infiltrated with an equivalent concentration of propranolol (Inderal, ICI). The possible mechanisms of the sweat response and whether these responses are analogous to those observed in the submaxillary glands of animals are discussed.