Porous hollow microspheres of amorphous calcium phosphate: soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery

and soybean lecithin in aqueous solution. This preparation method is facile, rapid, energy-saving and environment friendly. The effects of microwave hydrothermal temperature and concentrations of the reactants on the morphology and structure of the product were investigated. The as-prepared samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and Fourier-transform infrared (FTIR) spectroscopy. The as-prepared porous hollow microspheres of amorphous calcium phosphate are efficient for drug loading and release, and the drug delivery system shows a pH-responsive drug release behavior and high ability to damage tumor cells. Thus, the as-prepared porous hollow microspheres of amorphous calcium phosphate are promising for the applications in various biomedical fields.