July 1, 1998Tissue Antigens

Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease

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Why the study?

Are TNFA and TNFB polymorphisms associated with Chagas' disease or the development of chagasic chronic cardiomyopathy?

Structured PICO

Are TNFA and TNFB polymorphisms associated with Chagas' disease or the development of chagasic chronic cardiomyopathy?

Population

172 individuals from a Peruvian population endemic for Trypanosoma cruzi, including 85 serologically positive chagasic patients (33 with chagasic chronic cardiomyopathy, 52 asymptomatic) and 87 healthy controls.

Intervention

Presence of TNFA (positions -308, -244 and -238) and TNFB polymorphisms

Comparator

Healthy controls (for disease susceptibility) and asymptomatic chagasic patients (for cardiomyopathy development)

Outcome

Association of TNFA and TNFB polymorphisms with Chagas' disease and chagasic chronic cardiomyopathysurrogate

Polymorphisms at the TNFA and TNFB loci do not appear to be associated with susceptibility to Chagas' disease or the development of chagasic chronic cardiomyopathy in a Peruvian population.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No support for TNFA/TNFB genotyping in Chagas risk assessment; leaves open other genetic or environmental contributors.

Cite This Study

Beraún et al. (1998) studied this question.

synapsesocial.com/papers/6a91415aaa48ae0b05f0728a https://doi.org/10.1111/j.1399-0039.1998.tb03028.x

View Full Paper

Ask AI

Bookmark

Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease

Structured PICO

Discussion

Implication

Cite This Study

Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider