Key result
Endogenous T1ρ mapping detects peri-infarct zones with high accuracy, outperforming native T1 and T2 in chronic MI.
Why the study?
To evaluate the diagnostic performance of endogenous T1ρ mapping versus native T1 and T2 mapping for identifying LGE-defined peri-infarct zones in acute STEMI and chronic MI.
Does endogenous T1ρ mapping improve the identification of LGE-defined peri-infarct zones in patients with acute STEMI and chronic MI compared to native T1 and T2 mapping?
Observational (n=91)
Radiologists were blinded to clinical data and group assignment
No
Does endogenous T1ρ mapping improve the identification of LGE-defined peri-infarct zones in patients with acute STEMI and chronic MI compared to native T1 and T2 mapping?
Effect estimate: AUC 0.95 (95% CI 0.90-0.98)
Absolute Event Rate: 0.95% vs 0.88%
p-value: p=0.02
Endogenous T1ρ mapping provides a highly accurate, contrast-free imaging biomarker for characterizing peri-infarct myocardial tissue, performing comparably to T2 mapping in acute STEMI and superior to both native T1 and T2 mapping in chronic MI.
May support contrast-free peri-infarct mapping in MI; leaves open prospective validation before clinical adoption.
Purpose To evaluate the diagnostic performance of endogenous T1ρ mapping, compared with native T1 and T2 mapping, for identifying late gadolinium enhancement (LGE)-defined peri-infarct zones in acute ST-elevation myocardial infarction (STEMI) and chronic myocardial infarction (MI). Methods This retrospective study included 35 patients with acute STEMI, 21 with chronic MI, and 35 healthy controls who underwent cardiac MRI with T1ρ, native T1, and T2 mapping between March 2022 and August 2025. LGE was used to delineate peri-infarct zones in patients with MI. A linear mixed-effects model accounting for within-participant clustering compared T1ρ values across myocardial segments. Receiver operating characteristic analysis was used to assess diagnostic performance. Results Among the 56 patients with MI (mean age, 57 ± 13 years; 49 men), global T1ρ values were elevated in both acute STEMI and chronic MI compared with controls (both p < 0.001). T1ρ values were higher in peri-infarct zones than in control myocardium (all p < 0.05). For discriminating peri-infarct zones from control myocardium in acute STEMI, T1ρ (AUC, 0.95) performed comparably to T2 (AUC, 0.97; p = 0.11) and better than native T1 (AUC, 0.88; p = 0.02). In chronic MI, T1ρ (AUC, 0.91) outperformed native T1 (AUC, 0.81; p = 0.04) and T2 (AUC, 0.68; p < 0.001). Conclusion Endogenous T1ρ mapping may provide a contrast-free biomarker for myocardial tissue characterization in MI, with diagnostic performance comparable to T2 in acute STEMI and superior to native T1 and T2 in chronic MI.
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Li et al. (2026) conducted an observational in Acute ST-elevation myocardial infarction and chronic myocardial infarction (n=91). Endogenous T1ρ mapping vs. Native T1 and T2 mapping was evaluated on Diagnostic performance (AUC) for discriminating peri-infarct zones from control myocardium in acute STEMI (AUC 0.95, 95% CI 0.90-0.98, p=0.02). Endogenous T1ρ mapping accurately identified peri-infarct zones, performing comparably to T2 mapping in acute STEMI (AUC 0.95) and outperforming native T1 and T2 mapping in chronic MI (AUC 0.91).
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