Diagnosis of Post‐Infectious Bronchiolitis Obliterans: Guiding Treatment With Infant Pulmonary Function Testing

Q: What does this research mean for the field?

Infant pulmonary function testing can be utilized to diagnose and guide the treatment of post-infectious bronchiolitis obliterans following severe sequential viral respiratory infections. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jessica Reyes‐Angel; Jeremy Landeo‐Gutierrez; Daniel J. Weiner; Geoffrey Kurland

doi:10.1002/ppul.71792

August 25, 2026Pediatric PulmonologyOpen Access

Diagnosis of Post‐Infectious Bronchiolitis Obliterans: Guiding Treatment With Infant Pulmonary Function Testing

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Key Points

To describe the clinical course, diagnostic challenges, and therapeutic management of severe sequential viral respiratory failure associated with post-infectious bronchiolitis obliterans in an infant.
Clinical case evaluation of a 7-month-old male infant (born at 35 weeks' gestation) hospitalized for acute respiratory failure.
Serial diagnostic evaluations included viral nasal washings and chest radiography alongside treatment with mechanical ventilation, systemic steroids, bronchodilators, and antibiotics.
Initial respiratory failure secondary to Respiratory Syncytial Virus required systemic steroids, bronchodilators, and 5 days of mechanical ventilation prior to extubation.
Secondary clinical deterioration on hospital Day 10 with left lower lobe opacity and Adenovirus positivity necessitated reintubation for 11 additional days, followed by successful discharge without supplemental oxygen on Day 31.

Implication

Case report reveals severe biphasic viral respiratory failure in an infant, highlighting the clinical progression toward post-infectious bronchiolitis obliterans.

Abstract

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Cite This Study

Reyes‐Angel et al. (2026) studied this question.

synapsesocial.com/papers/6a9145ead15324a1df3a923b https://doi.org/10.1002/ppul.71792

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Diagnosis of Post‐Infectious Bronchiolitis Obliterans: Guiding Treatment With Infant Pulmonary Function Testing

Key Points

Implication

Abstract

Discussion

Cite This Study

Diagnosis of Post‐Infectious Bronchiolitis Obliterans: Guiding Treatment With Infant Pulmonary Function Testing

Key Points

Implication

Abstract

Discussion

Cite This Study

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