Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes

Figures

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  Figure 1. Changes in NYHA Functional class at baseline and at 3-Month, 6-Month and 1-Year after TEEMr.

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  Figure 2. Mitral regurgitation grade at different time points. Columns illustrate the fractions of MR grades, of the cohort of patients, at baseline, at the completion of TEEMr, at discharge and at 1-year follow-up. rMR grades at completion of TEEMr, at discharge and at 1-year follow-up were significantly lower compared to pre-intervention MR grades. There was no significant difference in rMR grades at completion of TEEMr and at discharge. MR, mitral regurgitation; TEEMr, transcatheter edge-to-edge mitral valve repair.

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  Figure 3. Mitral valve pressure gradient at completion of TEEMr and at discharge. (a) Changes in MVPG at TEEMr completion and at discharge. The cross-line marks the median of the measurements (50% quartile). The boxes represent the 25% to 75% interquartile values. The whiskers mark the smallest and largest measurements. The circles represent outliers. MVPG increased significantly (from 3 ± 1.4 mmHg at the completion of TEEMr to 3.7 ± 1.9 at discharge; p = 0.002); (b) Box plot of differences; MVPG, Mitral valve pressure gradient; TEEMr, Transcatheter edge-to-edge Mitral valve repair.

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  Figure 4. MVPG Correlation analysis at completion of TEEMr and at discharge. Scatter plots for Spearman’s correlation analysis between MVPG assessed by TEE at completion of TEEMr and MVPG assessed by TTE at discharge. Filled circles represent individual measurements. MVPG, Mitral valve pressure gradient; TEE, transesophageal echocardiography; TEEMr, Transcatheter edge-to-edge mitral valve repair; TTE, Transthoracic echocardiography.

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  Figure 5. Kaplan-Meier analyses for clinical endpoints. (a) Survival probability stratified by Immediate post-procedural rMR grade; (b) Survival probability stratified by rMR grade at discharge; (c) Freedom from first heart failure related hospitalization stratified by rMR grade at discharge; (d) Freedom from death or first heart failure related hospitalization stratified by rMR grade at discharge.