De Novo Design of a Novel Heterodinuclear Three‐Helix Bundle Metalloprotein

Peptides with coordination sites at both ends can be transformed to give a CuIIIRuII metalloprotein (shown schematically below) in a two-step process. Bipyridyl and histidine units bind RuII and CuII, respectively. This first de novo design of a heterodinuclear metalloprotein demonstrates the efficiency of metal-ion-assisted self assembly processes.