NEARLY 10 YEARS AGO, BURKE et al published an article in JAMA that set forth recommendations for care of individuals with an inherited predisposition to hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome, described as an autosomal dominant disorder, was characterized by predisposition to early onset colorectal cancer and cancers of the endometrium, small intestine, ovary, hepatobiliary system, kidney, and ureter. Discovery of the genes involved in this disorder meant that genetic testing could identify high-risk individuals. In addition, tumor phenotyping, which greatly facilitates identification of gene carriers, has become clinically available and has been recommended for a subset of individuals with colorectal cancer. This systematic review
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Lindor et al. (2006) studied this question.
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