Why the study?
Does surgical resection employing circulatory arrest improve survival in patients with cavo-atrial renal cell carcinoma?
Does surgical resection employing circulatory arrest improve survival in patients with cavo-atrial renal cell carcinoma?
Circulatory arrest is a relatively safe technique for removing renal carcinoma with cavo-atrial extension, with outcomes primarily limited by preoperative metastases and myocardial dysfunction.
Mixed outcomes in this small series should not change practice; leaves open any survival benefit of circulatory arrest in cavo-atrial renal cell carcinoma.
From 1990 to 1995, 12 patients with cavo-atrial renal cell carcinoma underwent resection of the tumor. Circulatory arrest was employed in 11/12 cases. The neoplasm extended to the inferior vena cava in two patients and to the intrahepatic veins or right atrium in five cases. Two severely cardiac compromised patients died perioperatively. Of five patients who showed preoperative suspicion of isolated metastases, 3 patients died postoperatively because of relapsing disease after a mean period of 10.8 months. Five patients are alive and doing well after a mean follow-up of 14.8 months. In our experience myocardial dysfunction determined poor immediate survival. Mid-term survival was influenced by preoperative metastases and lymph-node involvement, but not by intracaval extension. Circulatory arrest appears to be a relatively safe technique to remove renal carcinoma with cavo-atrial extension and should be indicated whenever there are no metastases.
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Francesco Donatelli (1998) studied this question.
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