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Size-dependent HW/BW ratios in rats challenge uniform normalization in models; extends allometric data but leaves open human translation.
The heart weight as well as the heart weight‐body weight ratios of 264 adult albino rats, 155 males and 109 females were analyzed. The large rats have significantly heavier hearts than small rats, but small adults have on the average significantly higher heart weight‐body weight ratios than large adults. The heart was partitioned and the ventricle weight‐body weight ratio was also determined. As would be expected boty the right and the left ventricles are heavier in large rats than in small rats. However, the small rats have on the average a significantly higher ventricle weight‐body weight ratio than large animals. Since there are highly significant differences between the weight of the heart of large and small animals, if heart weights are used in experimental work, rather than heart weight‐body weight ratios, the animals should have a narrow body weight range. It is thought that these data may be helpful to those who work on the heart of the rat.
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KRAMES et al. (1966) studied this question.
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